6ET4

HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH NOVEL INHIBITOR

6ET4 の概要

• エントリーDOI: 10.2210/pdb6et4/pdb
• 分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, ... (10 entities in total)
• 機能のキーワード: oxidoreductase, dhodh, cancer, p53 activation, pyrimidine synthesis
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Mitochondrion inner membrane ; Single-pass membrane protein : Q02127
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41863.70

構造登録者

Hakansson, M.,Walse, B.,Gustavsson, A.-L.,Lain, S. (登録日: 2017-10-25, 公開日: 2018-03-28, 最終更新日: 2024-01-17)

• 主引用文献: Ladds, M.J.G.W.,van Leeuwen, I.M.M.,Drummond, C.J.,Chu, S.,Healy, A.R.,Popova, G.,Pastor Fernandez, A.,Mollick, T.,Darekar, S.,Sedimbi, S.K.,Nekulova, M.,Sachweh, M.C.C.,Campbell, J.,Higgins, M.,Tuck, C.,Popa, M.,Safont, M.M.,Gelebart, P.,Fandalyuk, Z.,Thompson, A.M.,Svensson, R.,Gustavsson, A.L.,Johansson, L.,Farnegardh, K.,Yngve, U.,Saleh, A.,Haraldsson, M.,D'Hollander, A.C.A.,Franco, M.,Zhao, Y.,Hakansson, M.,Walse, B.,Larsson, K.,Peat, E.M.,Pelechano, V.,Lunec, J.,Vojtesek, B.,Carmena, M.,Earnshaw, W.C.,McCarthy, A.R.,Westwood, N.J.,Arsenian-Henriksson, M.,Lane, D.P.,Bhatia, R.,McCormack, E.,Lain, S.; A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.; Nat Commun, 9:1107-1107, 2018; PubMed: 29549331; DOI: 10.1038/s41467-018-03441-3

実験手法

X-RAY DIFFRACTION (1.7 Å)