6ESQ

Structure of the acetoacetyl-CoA thiolase/HMG-CoA synthase complex from Methanothermococcus thermolithotrophicus soaked with acetyl-CoA

Summary for 6ESQ

Entry DOI	10.2210/pdb6esq/pdb
Descriptor	acetoacetyl-CoA thiolase, Pfam DUF35, HydroxyMethylGlutaryl-CoA synthase, ... (9 entities in total)
Functional Keywords	isoprenoid synthesis, enzymatic channeling, mevalonate production, archaea, lipid biosynthesis, multi-enzymatic complex, scaffold protein, duf35 family, transferase
Biological source	Methanothermococcus thermolithotrophicus More
Total number of polymer chains	12
Total formula weight	381114.94
Authors	Voegeli, B.,Engilberge, S.,Girard, E.,Riobe, F.,Maury, O.,Erb, J.T.,Shima, S.,Wagner, T. (deposition date: 2017-10-24, release date: 2018-03-14, Last modification date: 2024-05-08)
Primary citation	Vogeli, B.,Engilberge, S.,Girard, E.,Riobe, F.,Maury, O.,Erb, T.J.,Shima, S.,Wagner, T. Archaeal acetoacetyl-CoA thiolase/HMG-CoA synthase complex channels the intermediate via a fused CoA-binding site. Proc. Natl. Acad. Sci. U.S.A., 115:3380-3385, 2018 Cited by PubMed: 29531083 DOI: 10.1073/pnas.1718649115 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.95 Å)

Structure validation