6ESQ

Structure of the acetoacetyl-CoA thiolase/HMG-CoA synthase complex from Methanothermococcus thermolithotrophicus soaked with acetyl-CoA

6ESQ の概要

• エントリーDOI: 10.2210/pdb6esq/pdb
• 分子名称: acetoacetyl-CoA thiolase, Pfam DUF35, HydroxyMethylGlutaryl-CoA synthase, ... (9 entities in total)
• 機能のキーワード: isoprenoid synthesis, enzymatic channeling, mevalonate production, archaea, lipid biosynthesis, multi-enzymatic complex, scaffold protein, duf35 family, transferase
• 由来する生物種: Methanothermococcus thermolithotrophicus; 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 381114.94

構造登録者

Voegeli, B.,Engilberge, S.,Girard, E.,Riobe, F.,Maury, O.,Erb, J.T.,Shima, S.,Wagner, T. (登録日: 2017-10-24, 公開日: 2018-03-14, 最終更新日: 2018-04-11)

• 主引用文献: Vogeli, B.,Engilberge, S.,Girard, E.,Riobe, F.,Maury, O.,Erb, T.J.,Shima, S.,Wagner, T.; Archaeal acetoacetyl-CoA thiolase/HMG-CoA synthase complex channels the intermediate via a fused CoA-binding site.; Proc. Natl. Acad. Sci. U.S.A., 115:3380-3385, 2018; PubMed: 29531083; DOI: 10.1073/pnas.1718649115

実験手法

X-RAY DIFFRACTION (2.95 Å)