6ESM
Crystal structure of MMP9 in complex with inhibitor BE4.
Summary for 6ESM
Entry DOI | 10.2210/pdb6esm/pdb |
Related | 5I12 6ELA |
Descriptor | Matrix metalloproteinase-9,Matrix metalloproteinase-9, ZINC ION, CALCIUM ION, ... (6 entities in total) |
Functional Keywords | metzincin, carboxylate inhibitor alternative zinc-binding groups, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 18663.56 |
Authors | Ciccone, L.,Tepshi, L.,Nuti, E.,Rossello, A.,Stura, E.A. (deposition date: 2017-10-23, release date: 2018-05-16, Last modification date: 2024-01-17) |
Primary citation | Nuti, E.,Cuffaro, D.,Bernardini, E.,Camodeca, C.,Panelli, L.,Chaves, S.,Ciccone, L.,Tepshi, L.,Vera, L.,Orlandini, E.,Nencetti, S.,Stura, E.A.,Santos, M.A.,Dive, V.,Rossello, A. Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies. J. Med. Chem., 61:4421-4435, 2018 Cited by PubMed: 29727184DOI: 10.1021/acs.jmedchem.8b00096 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.104 Å) |
Structure validation
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