6EQU

X-Ray crystal structure of the human carbonic anhydrase II adduct with a membrane-impermeant inhibitor

6EQU の概要

• エントリーDOI: 10.2210/pdb6equ/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, 4-[2-(2,4,6-triphenylpyridin-1-ium-1-yl)ethyl]benzenesulfonamide, ... (4 entities in total)
• 機能のキーワード: human carbonic anhydrase ii, membrane-impermeant inhibitor, complex, lyase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29903.14

構造登録者

Alterio, V.,De Simone, G.,Esposito, D. (登録日: 2017-10-15, 公開日: 2017-12-13, 最終更新日: 2024-01-17)

• 主引用文献: Alterio, V.,Esposito, D.,Monti, S.M.,Supuran, C.T.,De Simone, G.; Crystal structure of the human carbonic anhydrase II adduct with 1-(4-sulfamoylphenyl-ethyl)-2,4,6-triphenylpyridinium perchlorate, a membrane-impermeant, isoform selective inhibitor.; J Enzyme Inhib Med Chem, 33:151-157, 2018; PubMed: 29199489; DOI: 10.1080/14756366.2017.1405263

実験手法

X-RAY DIFFRACTION (1.65 Å)