6EKD

Crystal structure of JNK3 in complex with a pyridinylimidazole inhibitor

6EKD の概要

• エントリーDOI: 10.2210/pdb6ekd/pdb
• 分子名称: Mitogen-activated protein kinase 10, BETA-MERCAPTOETHANOL, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: protein kinase activity map kinase activity atp binding protein phosphorylation, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42782.55

構造登録者

Macedo, J.T.,Stehle, T.,Blaum, B.S. (登録日: 2017-09-26, 公開日: 2018-08-08, 最終更新日: 2024-01-17)

• 主引用文献: Ansideri, F.,Macedo, J.T.,Eitel, M.,El-Gokha, A.,Zinad, D.S.,Scarpellini, C.,Kudolo, M.,Schollmeyer, D.,Boeckler, F.M.,Blaum, B.S.,Laufer, S.A.,Koch, P.; Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38 alpha Mitogen-Activated Protein Kinase to c-Jun N-Terminal Kinase 3.; ACS Omega, 3:7809-7831, 2018; PubMed: 30087925; DOI: 10.1021/acsomega.8b00668

実験手法

X-RAY DIFFRACTION (2.1 Å)