6EGD

Crystal structure of the unphosphorylated IRAK4 kinase domain Bound to a type I inhibitor

6EGD の概要

• エントリーDOI: 10.2210/pdb6egd/pdb
• 分子名称: Interleukin-1 receptor-associated kinase 4, N-[2-methoxy-4-(morpholin-4-yl)phenyl]-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide (3 entities in total)
• 機能のキーワード: kinase, unphosphorylated, inactive, signaling protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68225.57

構造登録者

Ferrao, R.,Wu, H. (登録日: 2018-08-19, 公開日: 2019-02-13, 最終更新日: 2024-03-13)

• 主引用文献: Wang, L.,Ferrao, R.,Li, Q.,Hatcher, J.M.,Choi, H.G.,Buhrlage, S.J.,Gray, N.S.,Wu, H.; Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4).; J.Biol.Chem., 294:4511-4519, 2019; PubMed: 30679311; DOI: 10.1074/jbc.RA118.005428

実験手法

X-RAY DIFFRACTION (2.1 Å)