6EED

X-ray crystal structure of Pf-M1 in complex with inhibitor (6p) and catalytic zinc ion

Summary for 6EED

• Entry DOI: 10.2210/pdb6eed/pdb
• Descriptor: M1 family aminopeptidase, ZINC ION, (2R)-2-[(cyclohexylacetyl)amino]-N-hydroxy-2-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)acetamide, ... (8 entities in total)
• Functional Keywords: m1 alanyl-aminopeptidase, protease, inhibitor, hydroxamic acid, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Plasmodium falciparum (isolate FcB1 / Columbia)
• Total number of polymer chains: 1
• Total formula weight: 105032.43

Authors

Drinkwater, N.,McGowan, S. (deposition date: 2018-08-13, release date: 2018-12-26, Last modification date: 2024-03-13)

• Primary citation: Vinh, N.B.,Drinkwater, N.,Malcolm, T.R.,Kassiou, M.,Lucantoni, L.,Grin, P.M.,Butler, G.S.,Duffy, S.,Overall, C.M.,Avery, V.M.,Scammells, P.J.,McGowan, S.; Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases.; J. Med. Chem., 62:622-640, 2019; PubMed: 30537832; DOI: 10.1021/acs.jmedchem.8b01310

Experimental method

X-RAY DIFFRACTION (1.5 Å)