6EDR

Crystal Structure of Human CD38 in Complex with 4'-Thioribose NAD+

6EDR の概要

• エントリーDOI: 10.2210/pdb6edr/pdb
• 分子名称: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, [[(2~{R},3~{S},4~{R},5~{R})-5-(3-aminocarbonylpyridin-1-ium-1-yl)-3,4-bis(oxidanyl)thiolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate (3 entities in total)
• 機能のキーワード: inhibitor, cd38, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 60888.47

構造登録者

Dai, Z.,Zhang, X.N.,Nasertorabi, F.,Cheng, Q.,Pei, H.,Louie, S.G.,Stevens, C.R.,Zhang, Y. (登録日: 2018-08-10, 公開日: 2018-11-21, 最終更新日: 2024-05-15)

• 主引用文献: Dai, Z.,Zhang, X.N.,Nasertorabi, F.,Cheng, Q.,Pei, H.,Louie, S.G.,Stevens, R.C.,Zhang, Y.; Facile chemoenzymatic synthesis of a novel stable mimic of NAD.; Chem Sci, 9:8337-8342, 2018; PubMed: 30568770; DOI: 10.1039/c8sc03899f

実験手法

X-RAY DIFFRACTION (2.4 Å)