6EDC

hcGAS-16bp dsDNA complex

Summary for 6EDC

• Entry DOI: 10.2210/pdb6edc/pdb
• Descriptor: Cyclic GMP-AMP synthase, DNA (5'-D(*AP*AP*AP*TP*TP*GP*CP*CP*GP*AP*AP*GP*AP*CP*GP*AP*A)-3'), DNA (5'-D(*TP*TP*CP*GP*TP*CP*TP*TP*CP*GP*GP*CP*AP*AP*T)-3'), ... (4 entities in total)
• Functional Keywords: human cgas dna complex, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 53151.22

Authors

Xie, W.,Lama, L.,Adura, C.,Glickman, J.F.,Tuschl, T.,Patel, D.J. (deposition date: 2018-08-09, release date: 2019-05-29, Last modification date: 2023-10-11)

• Primary citation: Xie, W.,Lama, L.,Adura, C.,Tomita, D.,Glickman, J.F.,Tuschl, T.,Patel, D.J.; Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation.; Proc.Natl.Acad.Sci.USA, 116:11946-11955, 2019; PubMed: 31142647; DOI: 10.1073/pnas.1905013116

Experimental method

X-RAY DIFFRACTION (2.712 Å)