6EDC
hcGAS-16bp dsDNA complex
Summary for 6EDC
Entry DOI | 10.2210/pdb6edc/pdb |
Descriptor | Cyclic GMP-AMP synthase, DNA (5'-D(*AP*AP*AP*TP*TP*GP*CP*CP*GP*AP*AP*GP*AP*CP*GP*AP*A)-3'), DNA (5'-D(*TP*TP*CP*GP*TP*CP*TP*TP*CP*GP*GP*CP*AP*AP*T)-3'), ... (4 entities in total) |
Functional Keywords | human cgas dna complex, transferase-dna complex, transferase/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 53151.22 |
Authors | Xie, W.,Lama, L.,Adura, C.,Glickman, J.F.,Tuschl, T.,Patel, D.J. (deposition date: 2018-08-09, release date: 2019-05-29, Last modification date: 2023-10-11) |
Primary citation | Xie, W.,Lama, L.,Adura, C.,Tomita, D.,Glickman, J.F.,Tuschl, T.,Patel, D.J. Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation. Proc.Natl.Acad.Sci.USA, 116:11946-11955, 2019 Cited by PubMed: 31142647DOI: 10.1073/pnas.1905013116 PDB entries with the same primary citation |
Experimental method |
Structure validation
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