6E7R

Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-4

Summary for 6E7R

• Entry DOI: 10.2210/pdb6e7r/pdb
• Descriptor: Glutamate receptor ionotropic, NMDA 1, Glutamate receptor ionotropic, NMDA 2B, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: nmda receptor, ion channel, allosteric modulation, extracellular domain, transport protein
• Biological source: Xenopus laevis (African clawed frog); More
• Total number of polymer chains: 4
• Total formula weight: 172886.77

Authors

Regan, M.C.,Furukawa, H. (deposition date: 2018-07-27, release date: 2019-01-30, Last modification date: 2024-11-20)

• Primary citation: Regan, M.C.,Zhu, Z.,Yuan, H.,Myers, S.J.,Menaldino, D.S.,Tahirovic, Y.A.,Liotta, D.C.,Traynelis, S.F.,Furukawa, H.; Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors; Nat Commun, 10:321-, 2019

Experimental method

X-RAY DIFFRACTION (2.1 Å)