6E6M

Crystal structure of human cellular retinol-binding protein 1 in complex with cannabidiorcin (CBDO)

Summary for 6E6M

• Entry DOI: 10.2210/pdb6e6m/pdb
• Descriptor: Retinol-binding protein 1, (1'R,2'R)-4,5'-dimethyl-2'-(prop-1-en-2-yl)-1',2',3',4'-tetrahydro[1,1'-biphenyl]-2,6-diol (3 entities in total)
• Functional Keywords: vitamin a, retinol, cbdo, cannabidiorcin, lipid binding protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 3
• Total formula weight: 50481.67

Authors

Silvaroli, J.A.,Horwitz, S.,Banerjee, S.,Kiser, P.D.,Golczak, M. (deposition date: 2018-07-25, release date: 2019-02-13, Last modification date: 2024-03-13)

• Primary citation: Silvaroli, J.A.,Widjaja-Adhi, M.A.K.,Trischman, T.,Chelstowska, S.,Horwitz, S.,Banerjee, S.,Kiser, P.D.,Blaner, W.S.,Golczak, M.; Abnormal Cannabidiol Modulates Vitamin A Metabolism by Acting as a Competitive Inhibitor of CRBP1.; Acs Chem.Biol., 14:434-448, 2019; PubMed: 30721022; DOI: 10.1021/acschembio.8b01070

Experimental method

X-RAY DIFFRACTION (1.55 Å)