6E6E
DGY-06-116, a novel and selective covalent inhibitor of SRC kinase
Summary for 6E6E
Entry DOI | 10.2210/pdb6e6e/pdb |
Descriptor | Proto-oncogene tyrosine-protein kinase Src, N-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide (3 entities in total) |
Functional Keywords | proto-oncogene tyrosine-protein kinase src, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 8 |
Total formula weight | 258043.85 |
Authors | Gurbani, D.,Bera, A.,Westover, K. (deposition date: 2018-07-24, release date: 2019-07-31, Last modification date: 2023-10-11) |
Primary citation | Gurbani, D.,Du, G.,Henning, N.J.,Rao, S.,Bera, A.K.,Zhang, T.,Gray, N.S.,Westover, K.D. Structure and Characterization of a Covalent Inhibitor of Src Kinase. Front Mol Biosci, 7:81-81, 2020 Cited by PubMed: 32509799DOI: 10.3389/fmolb.2020.00081 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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