6E5T

Crystal structure of human cellular retinol binding protein 1 in complex with abnormal-cannabidiorcin (Abn-CBDO)

6E5T の概要

• エントリーDOI: 10.2210/pdb6e5t/pdb
• 分子名称: Retinol-binding protein 1, (1'R,2'R)-5',6-dimethyl-2'-(prop-1-en-2-yl)-1',2',3',4'-tetrahydro[1,1'-biphenyl]-2,4-diol (3 entities in total)
• 機能のキーワード: vitamin a, retinol, abn-cbdo, abnormal cannabidiorcin, lipid binding protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16827.22

構造登録者

Silvaroli, J.A.,Horwitz, S.,Banerjee, S.,Kiser, P.D.,Golczak, M. (登録日: 2018-07-23, 公開日: 2019-02-13, 最終更新日: 2023-10-11)

• 主引用文献: Silvaroli, J.A.,Widjaja-Adhi, M.A.K.,Trischman, T.,Chelstowska, S.,Horwitz, S.,Banerjee, S.,Kiser, P.D.,Blaner, W.S.,Golczak, M.; Abnormal Cannabidiol Modulates Vitamin A Metabolism by Acting as a Competitive Inhibitor of CRBP1.; Acs Chem.Biol., 14:434-448, 2019; PubMed: 30721022; DOI: 10.1021/acschembio.8b01070

実験手法

X-RAY DIFFRACTION (1.55 Å)