6E5P

Backbone model based on cryo-EM map at 8.5 A of domain-swapped, glycan-reactive, neutralizing antibody 2G12 bound to HIV-1 Env BG505 DS-SOSIP, which was also bound to CD4-binding site antibody VRC03

6E5P の概要

• エントリーDOI: 10.2210/pdb6e5p/pdb
• EMDBエントリー: 8981
• 関連するBIRD辞書のPRD_ID: PRD_900111
• 分子名称: 2G12 Light chain, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2G12 heavy chain, ... (10 entities in total)
• 機能のキーワード: hiv-1 env, complex, neutralizing, viral protein, domain-swapped antibody
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 24
• 化学式量合計: 658135.30

構造登録者

Acharya, P.,Kwong, P.D. (登録日: 2018-07-21, 公開日: 2019-02-13, 最終更新日: 2024-03-13)

• 主引用文献: Chuang, G.Y.,Zhou, J.,Acharya, P.,Rawi, R.,Shen, C.H.,Sheng, Z.,Zhang, B.,Zhou, T.,Bailer, R.T.,Dandey, V.P.,Doria-Rose, N.A.,Louder, M.K.,McKee, K.,Mascola, J.R.,Shapiro, L.,Kwong, P.D.; Structural Survey of Broadly Neutralizing Antibodies Targeting the HIV-1 Env Trimer Delineates Epitope Categories and Characteristics of Recognition.; Structure, 27:196-206.e6, 2019; PubMed: 30471922; DOI: 10.1016/j.str.2018.10.007

実験手法

ELECTRON MICROSCOPY (8.8 Å)