6E4U

Structure of AMPK bound to activator

Summary for 6E4U

Descriptor5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... (9 entities in total)
Functional Keywordskinase, ampk, activator, allostery, transferase-activator complex, transferase
Biological sourceRattus norvegicus (Rat)
Total number of polymer chains3
Total molecular weight120658.43
Authors
Calabrese, M.F.,Kurumbail, R.G. (deposition date: 2018-07-18, release date: 2018-08-08, Last modification date: 2018-09-05)
Primary citation
Ryder, T.F.,Calabrese, M.F.,Walker, G.S.,Cameron, K.O.,Reyes, A.R.,Borzilleri, K.A.,Delmore, J.,Miller, R.,Kurumbail, R.G.,Ward, J.,Kung, D.W.,Brown, J.A.,Edmonds, D.J.,Eng, H.,Wolford, A.C.,Kalgutkar, A.S.
Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK).
J. Med. Chem., 61:7273-7288, 2018
PubMed: 30036059 (PDB entries with the same primary citation)
DOI: 10.1021/acs.jmedchem.8b00807
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.27 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23440.9%6.7%5.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution