6E4U
Structure of AMPK bound to activator
Summary for 6E4U
Entry DOI | 10.2210/pdb6e4u/pdb |
Descriptor | 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... (9 entities in total) |
Functional Keywords | kinase, ampk, activator, allostery, transferase-activator complex, transferase |
Biological source | Rattus norvegicus (Rat) More |
Total number of polymer chains | 3 |
Total formula weight | 120658.43 |
Authors | Calabrese, M.F.,Kurumbail, R.G. (deposition date: 2018-07-18, release date: 2018-08-08, Last modification date: 2018-09-05) |
Primary citation | Ryder, T.F.,Calabrese, M.F.,Walker, G.S.,Cameron, K.O.,Reyes, A.R.,Borzilleri, K.A.,Delmore, J.,Miller, R.,Kurumbail, R.G.,Ward, J.,Kung, D.W.,Brown, J.A.,Edmonds, D.J.,Eng, H.,Wolford, A.C.,Kalgutkar, A.S. Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK). J. Med. Chem., 61:7273-7288, 2018 Cited by PubMed: 30036059DOI: 10.1021/acs.jmedchem.8b00807 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.27 Å) |
Structure validation
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