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6E40

Crystal structure of the indoleamine 2,3-dioxygenase 1 (IDO1) in complexed with ferric heme and Epacadostat

Summary for 6E40
Entry DOI10.2210/pdb6e40/pdb
DescriptorIndoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-{[2-(sulfamoylamino)ethyl]amino}-1,2,5-oxadiazole-3-carboximidamide, ... (4 entities in total)
Functional Keywordsido1, epacadostat, inhibitor complex, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total formula weight184984.24
Authors
Luo, S.,Tong, L. (deposition date: 2018-07-16, release date: 2018-11-14, Last modification date: 2024-03-13)
Primary citationLuo, S.,Xu, K.,Xiang, S.,Chen, J.,Chen, C.,Guo, C.,Tong, Y.,Tong, L.
High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form.
Acta Crystallogr F Struct Biol Commun, 74:717-724, 2018
Cited by
PubMed: 30387777
DOI: 10.1107/S2053230X18012955
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.306 Å)
Structure validation

217705

数据于2024-03-27公开中

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