6E3Y

Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor

Summary for 6E3Y

• Entry DOI: 10.2210/pdb6e3y/pdb
• EMDB information: 8978
• Descriptor: Calcitonin gene-related peptide 1, Nanobody 35, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... (7 entities in total)
• Functional Keywords: class b g protein-coupled receptor, agonist-receptor-g protein ternary complex, calcitonin gene-related peptide receptor, receptor activity modifying protein 1, active-state g protein-coupled receptor, signaling protein, phase plate, phase contrast
• Biological source: Lama glama (llama); More
• Total number of polymer chains: 7
• Total formula weight: 184355.96

Authors

Liang, Y.L.,Khoshouei, M.,Deganutti, G.,Glukhova, A.,Koole, C.,Peat, T.S.,Radjainia, M.,Plitzko, J.M.,Baumeister, W.,Miller, L.J.,Hay, D.L.,Christopoulos, A.,Reynolds, C.A.,Wootten, D.,Sexton, P.M. (deposition date: 2018-07-16, release date: 2018-09-19, Last modification date: 2020-01-15)

• Primary citation: Liang, Y.L.,Khoshouei, M.,Deganutti, G.,Glukhova, A.,Koole, C.,Peat, T.S.,Radjainia, M.,Plitzko, J.M.,Baumeister, W.,Miller, L.J.,Hay, D.L.,Christopoulos, A.,Reynolds, C.A.,Wootten, D.,Sexton, P.M.; Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor.; Nature, 561:492-497, 2018; PubMed: 30209400; DOI: 10.1038/s41586-018-0535-y

Experimental method

ELECTRON MICROSCOPY (3.3 Å)