6E3Y

Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor

6E3Y の概要

• エントリーDOI: 10.2210/pdb6e3y/pdb
• EMDBエントリー: 8978
• 分子名称: Calcitonin gene-related peptide 1, Nanobody 35, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... (7 entities in total)
• 機能のキーワード: class b g protein-coupled receptor, agonist-receptor-g protein ternary complex, calcitonin gene-related peptide receptor, receptor activity modifying protein 1, active-state g protein-coupled receptor, signaling protein, phase plate, phase contrast
• 由来する生物種: Lama glama (llama); 詳細
• タンパク質・核酸の鎖数: 7
• 化学式量合計: 184355.96

構造登録者

Liang, Y.L.,Khoshouei, M.,Deganutti, G.,Glukhova, A.,Koole, C.,Peat, T.S.,Radjainia, M.,Plitzko, J.M.,Baumeister, W.,Miller, L.J.,Hay, D.L.,Christopoulos, A.,Reynolds, C.A.,Wootten, D.,Sexton, P.M. (登録日: 2018-07-16, 公開日: 2018-09-19, 最終更新日: 2020-01-15)

• 主引用文献: Liang, Y.L.,Khoshouei, M.,Deganutti, G.,Glukhova, A.,Koole, C.,Peat, T.S.,Radjainia, M.,Plitzko, J.M.,Baumeister, W.,Miller, L.J.,Hay, D.L.,Christopoulos, A.,Reynolds, C.A.,Wootten, D.,Sexton, P.M.; Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor.; Nature, 561:492-497, 2018; PubMed: 30209400; DOI: 10.1038/s41586-018-0535-y

実験手法

ELECTRON MICROSCOPY (3.3 Å)