6E3E

Structure of RORgt in complex with a novel inverse agonist.

Summary for 6E3E

DescriptorNuclear receptor ROR-gamma, SULFATE ION, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (5 entities in total)
Functional Keywordsnuclear hormone receptor, inverse agonist, nuclear protein-agonist complex, nuclear protein/agonist
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight51853.86
Authors
Skene, R.J.,Hoffman, I. (deposition date: 2018-07-13, release date: 2019-07-17)
Primary citation
Yukawa, T.,Sato, A.,Kono, M.,Skene, R.J.,Shirai, J.,Yamamoto, S.
Design, Synthesis, and Biological Evaluation of Retinoic-acid-related orphan receptor (RORc) agonist
To Be Published,
Experimental method
X-RAY DIFFRACTION (2.47 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.21510 3.4% 6.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution