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6E3E

Structure of RORgt in complex with a novel inverse agonist.

Summary for 6E3E
Entry DOI10.2210/pdb6e3e/pdb
DescriptorNuclear receptor ROR-gamma, SULFATE ION, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (5 entities in total)
Functional Keywordsnuclear hormone receptor, inverse agonist, nuclear protein-agonist complex, nuclear protein/agonist
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight51853.86
Authors
Skene, R.J.,Hoffman, I. (deposition date: 2018-07-13, release date: 2019-07-17, Last modification date: 2024-03-13)
Primary citationYukawa, T.,Nara, Y.,Kono, M.,Sato, A.,Oda, T.,Takagi, T.,Sato, T.,Banno, Y.,Taya, N.,Imada, T.,Shiokawa, Z.,Negoro, N.,Kawamoto, T.,Koyama, R.,Uchiyama, N.,Skene, R.,Hoffman, I.,Chen, C.H.,Sang, B.,Snell, G.,Katsuyama, R.,Yamamoto, S.,Shirai, J.
Design, Synthesis, and Biological Evaluation of Retinoic Acid-Related Orphan Receptor gamma t (ROR gamma t) Agonist Structure-Based Functionality Switching Approach from In House ROR gamma t Inverse Agonist to ROR gamma t Agonist.
J.Med.Chem., 62:1167-1179, 2019
Cited by
PubMed: 30652849
DOI: 10.1021/acs.jmedchem.8b01181
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.47 Å)
Structure validation

217705

數據於2024-03-27公開中

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