6E3E
Structure of RORgt in complex with a novel inverse agonist.
Summary for 6E3E
Entry DOI | 10.2210/pdb6e3e/pdb |
Descriptor | Nuclear receptor ROR-gamma, SULFATE ION, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (5 entities in total) |
Functional Keywords | nuclear hormone receptor, inverse agonist, nuclear protein-agonist complex, nuclear protein/agonist |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 51853.86 |
Authors | Skene, R.J.,Hoffman, I. (deposition date: 2018-07-13, release date: 2019-07-17, Last modification date: 2024-03-13) |
Primary citation | Yukawa, T.,Nara, Y.,Kono, M.,Sato, A.,Oda, T.,Takagi, T.,Sato, T.,Banno, Y.,Taya, N.,Imada, T.,Shiokawa, Z.,Negoro, N.,Kawamoto, T.,Koyama, R.,Uchiyama, N.,Skene, R.,Hoffman, I.,Chen, C.H.,Sang, B.,Snell, G.,Katsuyama, R.,Yamamoto, S.,Shirai, J. Design, Synthesis, and Biological Evaluation of Retinoic Acid-Related Orphan Receptor gamma t (ROR gamma t) Agonist Structure-Based Functionality Switching Approach from In House ROR gamma t Inverse Agonist to ROR gamma t Agonist. J.Med.Chem., 62:1167-1179, 2019 Cited by PubMed: 30652849DOI: 10.1021/acs.jmedchem.8b01181 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.47 Å) |
Structure validation
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