6E3E

Structure of RORgt in complex with a novel inverse agonist.

6E3E の概要

分子名称Nuclear receptor ROR-gamma, SULFATE ION, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (5 entities in total)
機能のキーワードnuclear hormone receptor, inverse agonist, nuclear protein-agonist complex, nuclear protein/agonist
由来する生物種Homo sapiens (Human)
ポリマー鎖数2
分子量合計51853.86
構造登録者
Skene, R.J.,Hoffman, I. (登録日: 2018-07-13, 公開日: 2019-07-17)
主引用文献
Yukawa, T.,Sato, A.,Kono, M.,Skene, R.J.,Shirai, J.,Yamamoto, S.
Design, Synthesis, and Biological Evaluation of Retinoic-acid-related orphan receptor (RORc) agonist
To Be Published,
実験手法
X-RAY DIFFRACTION (2.47 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.21510 3.4% 6.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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