6E31

Crystal structure of RIAM in an autoinhibited configuration.

Summary for 6E31

DescriptorRap1-interacting adapter molecule (2 entities in total)
Functional Keywordsriam, rap1, lpd, adhesion, ras-association domain, pleckstrin-homology domain, autoinhibition, cell adhesion
Biological sourceMus musculus (Mouse)
Total number of polymer chains1
Total molecular weight41883.56
Authors
Chang, Y.C.,Su, W.,Zhang, H.,Huang, Q.,Philips, M.R.,Wu, J. (deposition date: 2018-07-12, release date: 2019-02-20, Last modification date: 2019-03-13)
Primary citation
Chang, Y.C.,Su, W.,Cho, E.A.,Zhang, H.,Huang, Q.,Philips, M.R.,Wu, J.
Molecular basis for autoinhibition of RIAM regulated by FAK in integrin activation.
Proc. Natl. Acad. Sci. U.S.A., 116:3524-3529, 2019
PubMed: 30733287 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1818880116
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.24310 2.4% 5.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6e31
no rotation
Molmil generated image of 6e31
rotated about x axis by 90°
Molmil generated image of 6e31
rotated about y axis by 90°