6E2O

ASK1 kinase domain complex with inhibitor

Summary for 6E2O

• Entry DOI: 10.2210/pdb6e2o/pdb
• Descriptor: Mitogen-activated protein kinase kinase kinase 5, 4-(4-cyclopropyl-1H-imidazol-1-yl)-N-[3-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)phenyl]pyridine-2-carboxamide (3 entities in total)
• Functional Keywords: protein kinase, inhibitor complex, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 67230.36

Authors

Lansdon, E.B. (deposition date: 2018-07-11, release date: 2018-09-19, Last modification date: 2018-10-17)

• Primary citation: Liles, J.T.,Corkey, B.K.,Notte, G.T.,Budas, G.R.,Lansdon, E.B.,Hinojosa-Kirschenbaum, F.,Badal, S.S.,Lee, M.,Schultz, B.E.,Wise, S.,Pendem, S.,Graupe, M.,Castonguay, L.,Koch, K.A.,Wong, M.H.,Papalia, G.A.,French, D.M.,Sullivan, T.,Huntzicker, E.G.,Ma, F.Y.,Nikolic-Paterson, D.J.,Altuhaifi, T.,Yang, H.,Fogo, A.B.,Breckenridge, D.G.; ASK1 contributes to fibrosis and dysfunction in models of kidney disease.; J. Clin. Invest., 128:4485-4500, 2018; PubMed: 30024858; DOI: 10.1172/JCI99768

Experimental method

X-RAY DIFFRACTION (2.389 Å)