Crystal structure of a class I PreQ1 riboswitch complexed with a synthetic compound 3: 2-[(9H-carbazol-3-yl)oxy]-N,N-dimethylethan-1-amine

Summary for 6E1V

DescriptorRNA (33-MER), 2-[(9H-carbazol-3-yl)oxy]-N,N-dimethylethan-1-amine (3 entities in total)
Functional Keywordspreq1 riboswitch, synthetic compound, complex, rna
Biological sourceCaldanaerobacter subterraneus subsp. tengcongensis
Total number of polymer chains1
Total molecular weight10478.43
Numata, T.,Connelly, C.M.,Schneekloth, J.S.,Ferre-D'Amare, A.R. (deposition date: 2018-07-10, release date: 2019-04-10, Last modification date: 2019-04-17)
Primary citation
Connelly, C.M.,Numata, T.,Boer, R.E.,Moon, M.H.,Sinniah, R.S.,Barchi, J.J.,Ferre-D'Amare, A.R.,Schneekloth Jr., J.S.
Synthetic ligands for PreQ1riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure.
Nat Commun, 10:1501-1501, 2019
PubMed: 30940810 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-019-09493-3
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRSRZ outliersRNA backbone 0.24830 0.52MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6e1v
no rotation
Molmil generated image of 6e1v
rotated about x axis by 90°
Molmil generated image of 6e1v
rotated about y axis by 90°