6DXK

Glucocorticoid Receptor in complex with Compound 11

6DXK の概要

• エントリーDOI: 10.2210/pdb6dxk/pdb
• 分子名称: Glucocorticoid receptor, (8S,11R,13S,14S,17S)-11-[4-(dimethylamino)phenyl]-17-(3,3-dimethylbut-1-yn-1-yl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one (non-preferred name) (3 entities in total)
• 機能のキーワード: signaling protein, nuclear hormone receptor, ligand complex, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 60277.96

構造登録者

Rew, Y.,Du, X.,Eksterowicz, J.,Zhou, H.,Jahchan, N.,Zhu, L.,Yan, X.,Kawai, H.,McGee, L.R.,Medina, J.C.,Huang, T.,Chen, C.,Zavorotinskaya, T.,Sutimantanapi, D.,Waszczuk, J.,Jackson, E.,Huang, E.,Ye, Q.,Fantin, V.R.,Daqing, S. (登録日: 2018-06-29, 公開日: 2018-10-03, 最終更新日: 2023-10-11)

• 主引用文献: Rew, Y.,Du, X.,Eksterowicz, J.,Zhou, H.,Jahchan, N.,Zhu, L.,Yan, X.,Kawai, H.,McGee, L.R.,Medina, J.C.,Huang, T.,Chen, C.,Zavorotinskaya, T.,Sutimantanapi, D.,Waszczuk, J.,Jackson, E.,Huang, E.,Ye, Q.,Fantin, V.R.,Sun, D.; Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101).; J. Med. Chem., 61:7767-7784, 2018; PubMed: 30091920; DOI: 10.1021/acs.jmedchem.8b00743

実験手法

X-RAY DIFFRACTION (3.05 Å)