6DXH

Structure of USP5 zinc-finger ubiquitin binding domain co-crystallized with 4-(4-tert-butylphenyl)-4-oxobutanoate

6DXH の概要

• エントリーDOI: 10.2210/pdb6dxh/pdb
• 分子名称: Ubiquitin carboxyl-terminal hydrolase 5, UNKNOWN ATOM OR ION, ZINC ION, ... (5 entities in total)
• 機能のキーワード: deubiquitinase, usp5, ubiquitin, structural genomics consortium, sgc, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13834.90

構造登録者

Harding, R.J.,Mann, M.K.,Ravichandran, M.,Ferreira de Freitas, R.,Franzoni, I.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Schapira, M.,Structural Genomics Consortium (SGC) (登録日: 2018-06-28, 公開日: 2018-07-18, 最終更新日: 2023-10-11)

• 主引用文献: Mann, M.K.,Franzoni, I.,de Freitas, R.F.,Tempel, W.,Houliston, S.,Smith, L.,Vedadi, M.,Arrowsmith, C.H.,Harding, R.J.,Schapira, M.; Discovery of Small Molecule Antagonists of the USP5 Zinc Finger Ubiquitin-Binding Domain.; J.Med.Chem., 62:10144-10155, 2019; PubMed: 31663737; DOI: 10.1021/acs.jmedchem.9b00988

実験手法

X-RAY DIFFRACTION (2 Å)