6DV4

HIV-1 wild type protease with GRL-04315A, a tetrahydronaphthalene carboxamide with (R)-Boc-amine and (S)-hydroxyl functionalities as the P2 ligand

6DV4 の概要

• エントリーDOI: 10.2210/pdb6dv4/pdb
• 関連するPDBエントリー: 2IEN 6DV0
• 分子名称: Protease, SODIUM ION, CHLORIDE ION, ... (7 entities in total)
• 機能のキーワード: aspartic acid protease, hiv-1 protease inhibitor of grl-04315a, tetrahydronaphthalene carboxamide, p2 ligand, drug resistance, design and synthesis, hydrolase, antiviral protein
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22422.25

構造登録者

Wang, Y.-F.,Agniswamy, J.,Weber, I.T. (登録日: 2018-06-22, 公開日: 2018-10-31, 最終更新日: 2023-10-11)

• 主引用文献: Ghosh, A.K.,Jadhav, R.D.,Simpson, H.,Kovela, S.,Osswald, H.,Agniswamy, J.,Wang, Y.F.,Hattori, S.I.,Weber, I.T.,Mitsuya, H.; Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors incorporating aminothiochromane and aminotetrahydronaphthalene carboxamide derivatives as the P2 ligands.; Eur J Med Chem, 160:171-182, 2018; PubMed: 30340140; DOI: 10.1016/j.ejmech.2018.09.046

実験手法

X-RAY DIFFRACTION (1.14 Å)