6DUP

CRYSTAL STRUCTURE OF PXR IN COMPLEX WITH COMPOUND 7

Summary for 6DUP

Entry DOI	10.2210/pdb6dup/pdb
Descriptor	Nuclear receptor subfamily 1 group I member 2, (2S)-2-({[3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]oxy}methyl)-2,3-dihydro-7H-[1,3]oxazolo[3,2-a]pyrimidin-7-one (3 entities in total)
Functional Keywords	pxr, nuclear protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	78756.41
Authors	Chen, X.,Zhang, Y.,Mclean, L.R. (deposition date: 2018-06-21, release date: 2018-08-29, Last modification date: 2024-03-13)
Primary citation	Vaz, R.J.,Li, Y.,Chellaraj, V.,Reiling, S.,Kuntzweiler, T.,Yang, D.,Shen, H.,Batchelor, J.D.,Zhang, Y.,Chen, X.,McLean, L.R.,Kosley Jr., R. Amelioration of PXR-mediated CYP3A4 induction by mGluR2 modulators. Bioorg. Med. Chem. Lett., 28:3194-3196, 2018 Cited by PubMed: 30146095 DOI: 10.1016/j.bmcl.2018.08.022 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation