6DUF
Crystal structure of HIV-1 reverse transcriptase V106A/F227L mutant in complex with non-nucleoside inhibitor 25a
Summary for 6DUF
Entry DOI | 10.2210/pdb6duf/pdb |
Related | 6C0N |
Descriptor | p66 RT, p51 RT, 4-({4-[(4-{4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy}thieno[3,2-d]pyrimidin-2-yl)amino]piperidin-1-yl}methyl)benzene-1-sulfonamide, ... (8 entities in total) |
Functional Keywords | hiv-1 reverse transcriptase, non-nucleoside inhibitor, replication |
Biological source | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) More |
Total number of polymer chains | 2 |
Total formula weight | 116625.60 |
Authors | Yang, Y.,Nguyen, L.A.,Smithline, Z.B.,Steitz, T.A. (deposition date: 2018-06-20, release date: 2018-08-01, Last modification date: 2023-10-11) |
Primary citation | Yang, Y.,Kang, D.,Nguyen, L.A.,Smithline, Z.B.,Pannecouque, C.,Zhan, P.,Liu, X.,Steitz, T.A. Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors. Elife, 7:-, 2018 Cited by PubMed: 30044217DOI: 10.7554/eLife.36340 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.963 Å) |
Structure validation
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