6DU2

Structure of Scp1 D96N bound to REST-pS861/4 peptide

Summary for 6DU2

Entry DOI	10.2210/pdb6du2/pdb
Descriptor	carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform X2, REST-pS861/4, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	phosphatase, transcription factor, phosphorylation, neurogenesis, hydrolase, hydrolase-peptide complex, hydrolase/peptide
Biological source	Erinaceus europaeus (Western European hedgehog) More
Total number of polymer chains	4
Total formula weight	44400.62
Authors	Burkholder, N.T.,Mayfield, J.E.,Yu, X.,Irani, S.,Arce, D.K.,Jiang, F.,Matthews, W.,Xue, Y.,Zhang, Y.J. (deposition date: 2018-06-19, release date: 2018-09-26, Last modification date: 2020-01-01)
Primary citation	Burkholder, N.T.,Mayfield, J.E.,Yu, X.,Irani, S.,Arce, D.K.,Jiang, F.,Matthews, W.L.,Xue, Y.,Zhang, Y.J. Phosphatase activity of small C-terminal domain phosphatase 1 (SCP1) controls the stability of the key neuronal regulator RE1-silencing transcription factor (REST). J. Biol. Chem., 293:16851-16861, 2018 Cited by PubMed: 30217818 DOI: 10.1074/jbc.RA118.004722 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation