6DU2

Structure of Scp1 D96N bound to REST-pS861/4 peptide

6DU2 の概要

• エントリーDOI: 10.2210/pdb6du2/pdb
• 分子名称: carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform X2, REST-pS861/4, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: phosphatase, transcription factor, phosphorylation, neurogenesis, hydrolase, hydrolase-peptide complex, hydrolase/peptide
• 由来する生物種: Erinaceus europaeus (Western European hedgehog); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 44400.62

構造登録者

Burkholder, N.T.,Mayfield, J.E.,Yu, X.,Irani, S.,Arce, D.K.,Jiang, F.,Matthews, W.,Xue, Y.,Zhang, Y.J. (登録日: 2018-06-19, 公開日: 2018-09-26, 最終更新日: 2020-01-01)

• 主引用文献: Burkholder, N.T.,Mayfield, J.E.,Yu, X.,Irani, S.,Arce, D.K.,Jiang, F.,Matthews, W.L.,Xue, Y.,Zhang, Y.J.; Phosphatase activity of small C-terminal domain phosphatase 1 (SCP1) controls the stability of the key neuronal regulator RE1-silencing transcription factor (REST).; J. Biol. Chem., 293:16851-16861, 2018; PubMed: 30217818; DOI: 10.1074/jbc.RA118.004722

実験手法

X-RAY DIFFRACTION (2.5 Å)