6DTW
HIV-1 Reverse Transcriptase Y181C Mutant in complex with JLJ 578
Summary for 6DTW
Entry DOI | 10.2210/pdb6dtw/pdb |
Descriptor | Reverse transcriptase/ribonuclease H, p51 RT, 8-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]-4-fluorophenoxy}-6-fluoroindolizine-2-carbonitrile, ... (6 entities in total) |
Functional Keywords | hiv-1, reverse transcriptase, inhibitor, hydrolase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) More |
Total number of polymer chains | 2 |
Total formula weight | 114513.42 |
Authors | Sasaki, T.,Gannam, Z.T.K.,Anderson, K.S.,Jorgensen, W.L.,Lee, W. (deposition date: 2018-06-18, release date: 2019-07-31, Last modification date: 2023-10-11) |
Primary citation | Sasaki, T.,Gannam, Z.T.K.,Kudalkar, S.N.,Frey, K.M.,Lee, W.G.,Spasov, K.A.,Jorgensen, W.L.,Anderson, K.S. Molecular and cellular studies evaluating a potent 2-cyanoindolizine catechol diether NNRTI targeting wildtype and Y181C mutant HIV-1 reverse transcriptase. Bioorg.Med.Chem.Lett., 29:2182-2188, 2019 Cited by PubMed: 31281023DOI: 10.1016/j.bmcl.2019.06.047 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.742 Å) |
Structure validation
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