6DR4

X-ray crystallographic structure of a covalent trimer derived from A-beta 17_36 containing the I31V point mutation

Summary for 6DR4

Entry DOI	10.2210/pdb6dr4/pdb
Descriptor	ORN-CYS-VAL-PHE-MEA-CYS-GLU-ASP-ORN-ALA-VAL-ILE-GLY-LEU-ORN-VAL, HEXANE-1,6-DIOL (3 entities in total)
Functional Keywords	amyloid, alzheimers disease, abeta, oligomer, de novo protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	7439.13
Authors	Salveson, P.J.,Nowick, J.S. (deposition date: 2018-06-11, release date: 2018-10-17, Last modification date: 2020-01-01)
Primary citation	Salveson, P.J.,Haerianardakani, S.,Thuy-Boun, A.,Yoo, S.,Kreutzer, A.G.,Demeler, B.,Nowick, J.S. Repurposing Triphenylmethane Dyes to Bind to Trimers Derived from A beta. J. Am. Chem. Soc., 140:11745-11754, 2018 Cited by PubMed: 30125493 DOI: 10.1021/jacs.8b06568 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.105 Å)

Structure validation