6DR4

X-ray crystallographic structure of a covalent trimer derived from A-beta 17_36 containing the I31V point mutation

6DR4 の概要

• エントリーDOI: 10.2210/pdb6dr4/pdb
• 分子名称: ORN-CYS-VAL-PHE-MEA-CYS-GLU-ASP-ORN-ALA-VAL-ILE-GLY-LEU-ORN-VAL, HEXANE-1,6-DIOL (3 entities in total)
• 機能のキーワード: amyloid, alzheimers disease, abeta, oligomer, de novo protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 7439.13

構造登録者

Salveson, P.J.,Nowick, J.S. (登録日: 2018-06-11, 公開日: 2018-10-17, 最終更新日: 2020-01-01)

• 主引用文献: Salveson, P.J.,Haerianardakani, S.,Thuy-Boun, A.,Yoo, S.,Kreutzer, A.G.,Demeler, B.,Nowick, J.S.; Repurposing Triphenylmethane Dyes to Bind to Trimers Derived from A beta.; J. Am. Chem. Soc., 140:11745-11754, 2018; PubMed: 30125493; DOI: 10.1021/jacs.8b06568

実験手法

X-RAY DIFFRACTION (2.105 Å)