6DQE

LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR N67 i.e. 2-(5-phenyl-4-(phenyl(2-(piperidin-1-yl)ethoxy)methyl)-1H-pyrazol-1-yl)isonicotinic acid

6DQE の概要

• エントリーDOI: 10.2210/pdb6dqe/pdb
• 分子名称: Linked KDM5A Jmj Domain, 2-(5-phenyl-4-{(R)-phenyl[2-(piperidin-1-yl)ethoxy]methyl}-1H-pyrazol-1-yl)pyridine-4-carboxylic acid, MANGANESE (II) ION, ... (6 entities in total)
• 機能のキーワード: demethylase inhibition, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38808.84

構造登録者

Horton, J.R.,Cheng, X. (登録日: 2018-06-10, 公開日: 2019-06-12, 最終更新日: 2023-10-11)

• 主引用文献: Horton, J.R.,Liu, X.,Woodcock, C.B.,Shanks, J.,Zhang, X.,Rai, G.,Mott, B.,Jansen, D.J.,Kales, S.,Henderson, M.J.,Pohida, K.,Fang, Y.,Hu, X.,Jadhav, A.,Maloney, D.,Hall, M.D.,Simeonov, A.,Fu, H.,Vertino, P.M.,Cheng, X.; To be determined; To Be Published,

実験手法

X-RAY DIFFRACTION (1.689 Å)