6DQ7
LINKED KDM5A JMJ DOMAIN BOUND TO THE POTENTIAL HYDROLYSIS PRODUCT OF INHIBITOR N45 i.e. 3-((6-(4-(2-cyano-3-methylbut-2-enoyl)-1,4-diazepan-1-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoic acid
6DQ7 の概要
エントリーDOI | 10.2210/pdb6dq7/pdb |
分子名称 | Linked KDM5A Jmj Domain, N-{6-[4-(hydroxyacetyl)-1,4-diazepan-1-yl]-2-(pyridin-2-yl)pyrimidin-4-yl}-beta-alanine, MANGANESE (II) ION, ... (6 entities in total) |
機能のキーワード | demethylase inhibition, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
由来する生物種 | Homo sapiens (Human) 詳細 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 38554.37 |
構造登録者 | |
主引用文献 | Horton, J.R.,Liu, X.,Woodcock, C.B.,Shanks, J.,Zhang, X.,Rai, G.,Mott, B.,Jansen, D.J.,Kales, S.,Henderson, M.J.,Pohida, K.,Fang, Y.,Hu, X.,Jadhav, A.,Maloney, D.,Hall, M.D.,Simeonov, A.,Fu, H.,Vertino, P.M.,Cheng, X. Structure-based Engineering of Reversible Covalent Inhibitors Against Histone Lysine Demethylase 5A To Be Published, |
実験手法 | X-RAY DIFFRACTION (1.852 Å) |
構造検証レポート
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