6DNB

Crystal structure of T110A:S256A mutant human Glutamate oxaloacetate transaminase 1 (GOT1)

6DNB の概要

• エントリーDOI: 10.2210/pdb6dnb/pdb
• 分子名称: Aspartate aminotransferase, cytoplasmic, TETRAETHYLENE GLYCOL, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: aspartate aminotransferase, glutamate oxaloacetate transaminase 1, got1, plp, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46809.77

構造登録者

Assar, Z.,Holt, M.C.,Stein, A.J.,Lairson, L.,Lyssiotis, C.A. (登録日: 2018-06-06, 公開日: 2018-11-14, 最終更新日: 2023-10-11)

• 主引用文献: Holt, M.C.,Assar, Z.,Beheshti Zavareh, R.,Lin, L.,Anglin, J.,Mashadova, O.,Haldar, D.,Mullarky, E.,Kremer, D.M.,Cantley, L.C.,Kimmelman, A.C.,Stein, A.J.,Lairson, L.L.,Lyssiotis, C.A.; Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors.; Biochemistry, 57:6604-6614, 2018; PubMed: 30365304; DOI: 10.1021/acs.biochem.8b00914

実験手法

X-RAY DIFFRACTION (1.7 Å)