6DN6

SPRY domain-containing SOCS box protein 2 complexed with INNN(ABU) cyclic peptide inhibitor

Summary for 6DN6

• Entry DOI: 10.2210/pdb6dn6/pdb
• Related PRD ID: PRD_002314
• Descriptor: SPRY domain-containing SOCS box protein 2, INNN(ABU) cyclic peptide inhibitor (3 entities in total)
• Functional Keywords: proteasomal degradation, nitric oxide, inhibitor, immune system, immune system-inhibitor complex, immune system/inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 24408.21

Authors

Law, R.H.P.,Caradoc-Davies, T.T.,Norton, R.S. (deposition date: 2018-06-06, release date: 2019-04-17, Last modification date: 2023-11-15)

• Primary citation: Sadek, M.M.,Barlow, N.,Leung, E.W.W.,Williams-Noonan, B.J.,Yap, B.K.,Shariff, F.M.,Caradoc-Davies, T.T.,Nicholson, S.E.,Chalmers, D.K.,Thompson, P.E.,Law, R.H.P.,Norton, R.S.; A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent.; ACS Chem. Biol., 13:2930-2938, 2018; PubMed: 30226743; DOI: 10.1021/acschembio.8b00561

Experimental method

X-RAY DIFFRACTION (1.59 Å)