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6DN0

Retrofitted antibodies with stabilizing mutations: Herceptin scFv mutant with VH K30D and VL S52D.

Replaces:  4X4Y
Summary for 6DN0
Entry DOI10.2210/pdb6dn0/pdb
DescriptorHuman Variable Heavy Chain of Herceptin containing VH mutation K30D, Human Variable Light Chain of Herceptin containing VL mutation S52D, FORMIC ACID, ... (4 entities in total)
Functional Keywordsherceptin, retrofit, stabilizing mutation, immune system
Biological sourceHomo sapiens
More
Total number of polymer chains4
Total formula weight51684.71
Authors
Langley, D.B.,Roome, B.,Christ, D. (deposition date: 2018-06-05, release date: 2019-06-12, Last modification date: 2023-10-11)
Primary citationRoome, B.,Langley, D.B.,Rouet, R.,Christ, D.
Retrofitting antibodies with stabilizing mutations
To Be Published,
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

217705

數據於2024-03-27公開中

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