6DN0
Retrofitted antibodies with stabilizing mutations: Herceptin scFv mutant with VH K30D and VL S52D.
Replaces: 4X4YSummary for 6DN0
Entry DOI | 10.2210/pdb6dn0/pdb |
Descriptor | Human Variable Heavy Chain of Herceptin containing VH mutation K30D, Human Variable Light Chain of Herceptin containing VL mutation S52D, FORMIC ACID, ... (4 entities in total) |
Functional Keywords | herceptin, retrofit, stabilizing mutation, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 4 |
Total formula weight | 51684.71 |
Authors | Langley, D.B.,Roome, B.,Christ, D. (deposition date: 2018-06-05, release date: 2019-06-12, Last modification date: 2023-10-11) |
Primary citation | Roome, B.,Langley, D.B.,Rouet, R.,Christ, D. Retrofitting antibodies with stabilizing mutations To Be Published, |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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