6DN0

Retrofitted antibodies with stabilizing mutations: Herceptin scFv mutant with VH K30D and VL S52D.

Replaces:  4X4Y

Summary for 6DN0

• Entry DOI: 10.2210/pdb6dn0/pdb
• Descriptor: Human Variable Heavy Chain of Herceptin containing VH mutation K30D, Human Variable Light Chain of Herceptin containing VL mutation S52D, FORMIC ACID, ... (4 entities in total)
• Functional Keywords: herceptin, retrofit, stabilizing mutation, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 4
• Total formula weight: 51684.71

Authors

Langley, D.B.,Roome, B.,Christ, D. (deposition date: 2018-06-05, release date: 2019-06-12, Last modification date: 2024-10-23)

• Primary citation: Roome, B.,Langley, D.B.,Rouet, R.,Christ, D.; Retrofitting antibodies with stabilizing mutations; To Be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)