6DKI
Crystal structure of Trk-A in complex with the Pan-Trk Kinase Inhibitor, compound 19.
6DKI の概要
エントリーDOI | 10.2210/pdb6dki/pdb |
関連するPDBエントリー | 6DKB 6DKG |
分子名称 | High affinity nerve growth factor receptor, 5-phenylthieno[2,3-d]pyrimidin-4(3H)-one, 6-amino-5-{[(3S)-4,4-difluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}pyrrolidin-3-yl]oxy}-N-methylpyridine-3-carboxamide, ... (4 entities in total) |
機能のキーワード | inhibitor tyrosine kinase, transferase, pan-trk kinase, treatment for pain, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 36813.15 |
構造登録者 | Greasley, S.E.,Johnson, E.,Kraus, M.L.,Cronin, C.N. (登録日: 2018-05-29, 公開日: 2018-07-11, 最終更新日: 2024-03-13) |
主引用文献 | Bagal, S.K.,Andrews, M.,Bechle, B.M.,Bian, J.,Bilsland, J.,Blakemore, D.C.,Braganza, J.F.,Bungay, P.J.,Corbett, M.S.,Cronin, C.N.,Cui, J.J.,Dias, R.,Flanagan, N.J.,Greasley, S.E.,Grimley, R.,James, K.,Johnson, E.,Kitching, L.,Kraus, M.L.,McAlpine, I.,Nagata, A.,Ninkovic, S.,Omoto, K.,Scales, S.,Skerratt, S.E.,Sun, J.,Tran-Dube, M.,Waldron, G.J.,Wang, F.,Warmus, J.S. Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain. J. Med. Chem., 61:6779-6800, 2018 Cited by PubMed: 29944371DOI: 10.1021/acs.jmedchem.8b00633 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.11 Å) |
構造検証レポート
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