6DK1

Human sigma-1 receptor bound to (+)-pentazocine

Summary for 6DK1

• Entry DOI: 10.2210/pdb6dk1/pdb
• Descriptor: Sigma non-opioid intracellular receptor 1, (2S,6S,11S)-6,11-dimethyl-3-(3-methylbut-2-en-1-yl)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-8-ol, SULFATE ION, ... (6 entities in total)
• Functional Keywords: membrane protein, antagonist bound, receptor, sigma-1 receptor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 3
• Total formula weight: 82835.11

Authors

Schmidt, H.R.,Kruse, A.C. (deposition date: 2018-05-28, release date: 2018-10-17, Last modification date: 2023-10-11)

• Primary citation: Schmidt, H.R.,Betz, R.M.,Dror, R.O.,Kruse, A.C.; Structural basis for sigma1receptor ligand recognition.; Nat. Struct. Mol. Biol., 25:981-987, 2018; PubMed: 30291362; DOI: 10.1038/s41594-018-0137-2

Experimental method

X-RAY DIFFRACTION (3.12 Å)