6DJ0

ASLTVS segment from Human Immunoglobulin Light-Chain Variable Domain, Residues 73-78, assembled as an amyloid fibril

Summary for 6DJ0

• Entry DOI: 10.2210/pdb6dj0/pdb
• Related: 6DIX 6DIY
• Descriptor: ASLTVS segment from Light-Chain Variable Domain, Lambda Mcg (2 entities in total)
• Functional Keywords: amyloid fibril, protein fibril
• Biological source: Homo sapiens
• Total number of polymer chains: 2
• Total formula weight: 1153.28

Authors

Brumshtein, B.,Esswein, S.R.,Sawaya, M.R.,Eisenberg, D.S. (deposition date: 2018-05-24, release date: 2018-10-31, Last modification date: 2024-04-03)

• Primary citation: Brumshtein, B.,Esswein, S.R.,Sawaya, M.R.,Rosenberg, G.,Ly, A.T.,Landau, M.,Eisenberg, D.S.; Identification of two principal amyloid-driving segments in variable domains of Ig light chains in systemic light-chain amyloidosis.; J. Biol. Chem., 293:19659-19671, 2018; PubMed: 30355736; DOI: 10.1074/jbc.RA118.004142

Experimental method

X-RAY DIFFRACTION (1.3 Å)