6DIU

Crystal structure of HCV NS3/4A protease in complex with P4-3(AJ-74)

Summary for 6DIU

• Entry DOI: 10.2210/pdb6diu/pdb
• Descriptor: NS3 protease, ZINC ION, SULFATE ION, ... (6 entities in total)
• Functional Keywords: ns3/4a protease, hepatitis c virus, drug resistance, protease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase, hydrolase/hydrolase inhibitor
• Biological source: Hepacivirus C
• Total number of polymer chains: 1
• Total formula weight: 22866.07

Authors

Matthew, A.N.,Schiffer, C.A. (deposition date: 2018-05-23, release date: 2019-07-31, Last modification date: 2023-10-11)

• Primary citation: Matthew, A.N.,Schiffer, C.A.; Design of Hepatitis C NS3/4A Protease Inhibitors Leveraging Untapped Regions of the Substrate Envelope; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.868 Å)