6DGR

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with CAY10638

6DGR の概要

分子名称Peroxisome proliferator-activated receptor gamma, (5Z)-5-({4-[2-(thiophen-2-yl)ethoxy]phenyl}methylidene)-1,3-thiazolidine-2,4-dione (3 entities in total)
機能のキーワードnuclear receptors, tzds, drug design, therapeutic targets, transcription, transcription-transcription inhibitor complex, transcription/transcription inhibitor
由来する生物種Homo sapiens (Human)
ポリマー鎖数2
分子量合計68636.25
構造登録者
Shang, J.,Kojetin, D.J. (登録日: 2018-05-18, 公開日: 2019-05-22)
主引用文献
Shang, J.,Kojetin, D.J.
Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with CAY10638
To Be Published,
実験手法
X-RAY DIFFRACTION (2.15 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.26210 1.6% 2.2% 7.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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