6DGL

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with Darglitazone

6DGL の概要

• エントリーDOI: 10.2210/pdb6dgl/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, (5Z)-5-({4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propanoyl]phenyl}methylidene)-1,3-thiazolidine-2,4-dione (3 entities in total)
• 機能のキーワード: nuclear receptors, tzds, drug design, therapeutic targets, transcription, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 63850.08

構造登録者

Shang, J.,Kojetin, D.J. (登録日: 2018-05-17, 公開日: 2019-05-22, 最終更新日: 2023-10-11)

• 主引用文献: Shang, J.,Brust, R.,Griffin, P.R.,Kamenecka, T.M.,Kojetin, D.J.; Quantitative structural assessment of graded receptor agonism.; Proc.Natl.Acad.Sci.USA, 116:22179-22188, 2019; PubMed: 31611383; DOI: 10.1073/pnas.1909016116

実験手法

X-RAY DIFFRACTION (1.95 Å)