6DFW

TCR 8F10 in complex with IAg7-p8G9E

Summary for 6DFW

Related6DFV
DescriptorH-2 class II histocompatibility antigen, A-D alpha chain, H2-Ab1 protein, 8F10 alpha chain, ... (4 entities in total)
Functional Keywordst cell receptor, type 1 diabetes, autoimmunity, immune system
Biological sourceMus musculus (Mouse)
Total number of polymer chains8
Total molecular weight192966.84
Authors
Wang, Y.,Dai, S. (deposition date: 2018-05-15, release date: 2019-04-17)
Primary citation
Wang, Y.,Sosinowski, T.,Novikov, A.,Crawford, F.,White, J.,Jin, N.,Liu, Z.,Zou, J.,Neau, D.,Davidson, H.W.,Nakayama, M.,Kwok, W.W.,Gapin, L.,Marrack, P.,Kappler, J.W.,Dai, S.
How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes.
Sci Immunol, 4:-, 2019
PubMed: 30952805 (PDB entries with the same primary citation)
DOI: 10.1126/sciimmunol.aav7517
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.30119 5.7% 17.3% 4.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (6dfw.pdb2.gz [275.09 KB])
Coordinate files for Biological unit (6dfw.pdb1.gz [261.99 KB])